diff --git a/pkg/database/custom_migrations.go b/pkg/database/custom_migrations.go
new file mode 100644
index 000000000..d3c234548
--- /dev/null
+++ b/pkg/database/custom_migrations.go
@@ -0,0 +1,69 @@
+package database
+
+import (
+	"database/sql"
+	"strings"
+
+	"github.com/jmoiron/sqlx"
+	"github.com/stashapp/stash/pkg/logger"
+)
+
+func runCustomMigrations() error {
+	if err := createImagesChecksumIndex(); err != nil {
+		return err
+	}
+
+	return nil
+}
+
+func createImagesChecksumIndex() error {
+	return WithTxn(func(tx *sqlx.Tx) error {
+		row := tx.QueryRow("SELECT 1 AS found FROM sqlite_master WHERE type = 'index' AND name = 'images_checksum_unique'")
+		err := row.Err()
+		if err != nil && err != sql.ErrNoRows {
+			return err
+		}
+
+		if err == nil {
+			var found bool
+			row.Scan(&found)
+			if found {
+				return nil
+			}
+		}
+
+		_, err = tx.Exec("CREATE UNIQUE INDEX images_checksum_unique ON images (checksum)")
+		if err == nil {
+			_, err = tx.Exec("DROP INDEX IF EXISTS index_images_checksum")
+			if err != nil {
+				logger.Errorf("Failed to remove surrogate images.checksum index: %s", err)
+			}
+			logger.Info("Created unique constraint on images table")
+			return nil
+		}
+
+		_, err = tx.Exec("CREATE INDEX IF NOT EXISTS index_images_checksum ON images (checksum)")
+		if err != nil {
+			logger.Errorf("Unable to create index on images.checksum: %s", err)
+		}
+
+		var result []struct {
+			Checksum string `db:"checksum"`
+		}
+
+		err = tx.Select(&result, "SELECT checksum FROM images GROUP BY checksum HAVING COUNT(1) > 1")
+		if err != nil && err != sql.ErrNoRows {
+			logger.Errorf("Unable to determine non-unique image checksums: %s", err)
+			return nil
+		}
+
+		checksums := make([]string, len(result))
+		for i, res := range result {
+			checksums[i] = res.Checksum
+		}
+
+		logger.Warnf("The following duplicate image checksums have been found. Please remove the duplicates and restart. %s", strings.Join(checksums, ", "))
+
+		return nil
+	})
+}
diff --git a/pkg/database/database.go b/pkg/database/database.go
index f2aa58734..017a3497a 100644
--- a/pkg/database/database.go
+++ b/pkg/database/database.go
@@ -23,7 +23,7 @@ import (
 var DB *sqlx.DB
 var WriteMu *sync.Mutex
 var dbPath string
-var appSchemaVersion uint = 27
+var appSchemaVersion uint = 28
 var databaseSchemaVersion uint
 
 var (
@@ -86,6 +86,10 @@ func Initialize(databasePath string) error {
 	DB = open(databasePath, disableForeignKeys)
 	WriteMu = &sync.Mutex{}
 
+	if err := runCustomMigrations(); err != nil {
+		return err
+	}
+
 	return nil
 }
 
diff --git a/pkg/database/migrations/28_images_indexes.up.sql b/pkg/database/migrations/28_images_indexes.up.sql
new file mode 100644
index 000000000..1fbb1cfe2
--- /dev/null
+++ b/pkg/database/migrations/28_images_indexes.up.sql
@@ -0,0 +1,3 @@
+DROP INDEX IF EXISTS `images_path_unique`;
+
+CREATE UNIQUE INDEX `images_path_unique` ON `images` (`path`);
diff --git a/ui/v2.5/src/components/Changelog/versions/v0100.md b/ui/v2.5/src/components/Changelog/versions/v0100.md
index cd6b2aa1b..a332998d3 100644
--- a/ui/v2.5/src/components/Changelog/versions/v0100.md
+++ b/ui/v2.5/src/components/Changelog/versions/v0100.md
@@ -1,3 +1,5 @@
+#### 💥 Note: Please check your logs after migrating to this release. A log warning will be generated on startup if duplicate image checksums exist in your system. Search for the images using the logged checksums, and remove the unwanted ones.
+
 ### ✨ New Features
 * Added options to generate webp and static preview files for markers. ([#1604](https://github.com/stashapp/stash/pull/1604))
 * Added sort by option for gallery rating. ([#1720](https://github.com/stashapp/stash/pull/1720))
@@ -10,6 +12,7 @@
 * Support filtering Movies by Performers. ([#1675](https://github.com/stashapp/stash/pull/1675))
 
 ### 🎨 Improvements
+* Added missing image table indexes, resulting in a significant performance improvement. ([#1740](https://github.com/stashapp/stash/pull/1740))
 * Support scraper script logging to specific log levels. ([#1648](https://github.com/stashapp/stash/pull/1648))
 * Added sv-SE language option. ([#1691](https://github.com/stashapp/stash/pull/1691))